dog won't eat

Aratana developed a first-of-its-kind ghrelin receptor agonist, ENTYCE® (capromorelin oral solution), which was granted FDA approval for appetite stimulation in dogs. We believe this new therapeutic will help veterinarians manage the symptom of inappetence while working to diagnose the underlying cause. Historically, veterinarians have relied on non-FDA-approved therapies that were not specifically designed to stimulate appetite and offered variable levels of both safety and efficacy. Now, with the FDA approval of ENTYCE, safe and effective appetite stimulation in dogs is possible.

More than 10 million dogs in the United States present annually to their veterinarian with the symptom of inappetence.1 The prolonged negative physiologic effects of inappetence in dogs are well documented and can lead to serious metabolic derangements.2 In addition, inappetence can represent a major negative perception of the quality of life to the caregiver, which may be especially distressful and is often perceived as evidence of suffering.

There are generally two causes of inappetence:

  • Pseudoinappetence, which may occur due to dental disease, unpalatable food or food aversions
  • True inappetence, which may be caused by one or more conditions, such as, but not limited to a systemic disease (e.g. renal disease, cancer), pain, nausea, medications, respiratory distress, neurologic disease or congestive heart failure.



ENTYCE® (capromorelin oral solution) is a flavored, liquid prescription product administered orally using the provided syringe. As a selective ghrelin receptor agonist, it mimics ghrelin, the naturally-occurring “hunger hormone” and a peptide produced in the stomach that is integral to the regulation of food intake. Ghrelin binds to receptors in the hypothalamus, initiating signaling cascades to trigger appetite.4

Aratana intends to commercially launch ENTYCE by the fall of 2017. Learn more about inappetence and download clinical research findings in the Aratana Library.

appetite stimulant

Important Safety Information

ENTYCE® (capromorelin oral solution) is for use in dogs only. Do not use in breeding, pregnant or lactating dogs. Use with caution in dogs with hepatic dysfunction or renal insufficiency.  Adverse reactions in dogs may include diarrhea, vomiting, polydipsia, and hypersalivation. Should not be used in dogs that have a hypersensitivity to capromorelin. Please see the full Prescribing Information for more detail.


  1. Data on file.
  2. Hershey AE, et al. “Quality of Life Assessment in the Veterinary Cancer Patient”. Veterinary Comparative Oncology Group, a division of Veterinary Cancer Society. http://www.vetcancersociety.org/members/cooperative-oncology-group/ 10 March 2016
  3. Ettinger, S.J. (2010). Chapter 41 (Anorexia) in the Textbook of Veterinary Internal Medicine, 7th ed. St. Louis, MO. Saunders Elsevier.
  4. ENTYCE® (capromorelin oral solution) Package Insert. Leawood, KS: Aratana Therapeutics, 2016.

Additional resources:

Related News Posts